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Lamm SH, Levine MS, Starr JA, Tirey SL. QA/review: MC, PB, and KM. Identify causations- how did that happen? We conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc in humans. In:Dusts and Disease, Lemen R., Dement J.M, , editors. IARC. The authors reported a reduced exposure odds ratio (OR = 0.73; CI not reported) for cohort members in the highest cumulative talc exposure group (800 mg/m3-years). The pulmonary toxicity of talc and granite dust as estimated from an in vivo hamster bioassay. The relevance of the rat lung response to particle overload for human risk assessment: a workshop consensus report. Generally, aerosolized talc has an alveolar biological half-life of about 710 days in animals. Overall, the mechanistic evidence is insufficient to support an MOA whereby talc induces pulmonary carcinogenesis. EPA Doc. Wehner AP, Stuart BO, Sanders CL. Shim I, Kim HM, Yang S, Choi M, Seo GB, Lee BW, et al. Health Hazard Evaluation Report: R.T. Vanderbilt Company, Gouverneur, NY. Our speech and language therapist will assess your childs receptive language abilities and identify where their difficulties lie. The authors reported issues with the consistency of administration of talc aerosol over some weeks in the middle of the study, likely resulting in increased talc exposure. Authors HL, KM, WT, DL, OL, JC, KC, RF, MC, AI, and AU are employed by Stantec ChemRisk, a consulting firm that provides scientific support to the government, corporations, law firms, and various scientific/professional organizations. Chem Biol Interact. Based on the quality evaluation methods (see Materials and methods), the three studies assessing talc toxicology in animals were rated as high quality. However, macrophage numbers decreased in days 414, and remained decreased, indicative of a chronic effect. The Italian, Norwegian, French, and Austrian talc mines all produced talcs described as non-asbestiform with various accessory minerals including small amounts of chlorite and quartz (30, 50, 52). In brief, selected literature pertained to talc exposure via inhalation and addressed potential associations with lung cancers or pleural mesothelioma. the objective of this paper was to apply systematic review methods to critically evaluate and synthesize the scientific evidence addressing the possible relationship (s) between exposure to talc occupationally and from exposure to talc-containing products (primarily talcum powders and cosmetics) and pulmonary cancers, specifically lung 43. Safety assessment of talc as used in cosmetics. This can impact certain aspects of social and academic development. Inhalation studies with Syrian golden hamsters. The Test of Abstract Language Comprehension can be used by speech and language therapists to assess your childs understanding of concrete and abstract language through different style questions. s xr%LD%U\C : 80-115. (1974) 16:3459. Markers of inflammation also have been observed in the lungs of rats after talc exposure, but one of the only available mechanistic studies utilized a route of exposure (i.e., intratracheal instillation) that is not comparable to inhalation exposures. This might have introduced confounding, as short-term or transient workers tend to have a higher prevalence of smoking and other health risk factors (46). Talc has been reported to cause fever in 16 to 69% of patients. Eur Resp J. Albumin, a marker of pulmonary edema, also was increased. EFSA journal. Each of the five DAYC-2 domains Cognition, Communication, Social-Emotional Development, Physical Development, and Adaptive Behavior reflects an area mandated for assessment and intervention for young children in IDEA. doi: 10.1136/oem.59.2.98, 31. WebEach of the five DAYC-2 domains Cognition, Communication, Social-Emotional Development, Physical Development, and Adaptive Behavior reflects an area The EFSA Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion reevaluating the safety of calcium silicate, magnesium silicate and talc when used as food additives, finding that there is no mechanistic rationale for a group ADI for silicates and silicon dioxide and the groupADI established by the SCF is obsolete. p. 379-88. If you would like more information on the assessment please email Most of the available studies that evaluated lung cancers were rated medium quality. Earn money by contributing to product development. doi: 10.1007/BF00517952, 32. Inhal Toxicol. 0000059557 00000 n A few studies reported excess lung cancer mortality, but lung cancer mortality risk did not increase with increasing talc exposure and the association potentially was confounded by smoking. The molecular formula for talc is Mg3Si4O10(OH)2. The TROG-2 is a fully revised and nationally re-standardised version of the widely used TROG. (1993) 64:44956. : 238-877-9. EPA. @$` g Children can often struggle to understand what is being said, what people mean by what they have said and assume situations and thoughts. Drechsel DA, Barlow CA, Bare JL, Jacobs NF, Henshaw JL. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Malignant mesothelioma following repeated exposures to cosmetic talc: a case series of 75 patients. Historical air sampling records were used to estimate cumulative dust exposure for each worker. 0000004445 00000 n These reported results for exposure and NMRD mortality underscore the magnitude of historical exposures and consequent health risks. 0000000016 00000 n Figure 2. Our expert speech and language therapists provide a range of services for children with eating, drinking and swallowing difficulties, alongside our professionals multidisciplinary team. 11. Endo-Capron S, Fleury-Feith J, Nebut M, Neef RD, Jaurand M. Some in vivo and in vitro studies carried out with talc samples. This assessment presents information relevant to the safety of talc as used in cosmetic formulations. 1322 50 When stratified by employment history, talc workers with known prior employment also showed excess lung cancer mortality (SMR = 2.14; no CI reported), and talc workers with no known work prior to their talc facility employment showed a slight deficit of lung cancer deaths (SMR = 0.76; no CI reported). Int Arch Occup Environ Health. Literature search and selection process. EPA/600/R-20/137 November 2020. (2020) 63:4849. Acta Oncol. No. Published in International journal of toxicology 2015, Monice M. Fiume, I. Boyer, +9 authors F. A. Andersen. The higher quality studies generally did not demonstrate an association, or attributed observed increased risks to potential confounding by cigarette smoking, as risks did not correlate with indicators of talc exposure. Particle overload is common when high doses of poorly insoluble particles are administered particle clearance mechanisms of the lung are overwhelmed and carcinogenic processes are initiated (23, 24): see Mechanistic evidence and Mode of Action. There was no evidence of carcinogenicity in mice exposed to talc. 47. After excluding studies based on exposure route, non-pulmonary outcome, and administration of talc as part of a mixture, three studies remained for study quality evaluation (1719). doi: 10.1080/08958378.2020.1781304, Keywords: systematic review, talc, hazard assessment, carcinogenicity, risk assessment, lung cancer, mesothelioma, Citation: Lynch HN, Lauer DJ, Thompson WJ, Leleck O, Freid RD, Collins J, Chen K, Ierardi AM, Urban AM, Cappello MA, Boffetta P and Mundt KA (2022) Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc. 7.2 Exposure assessment. 14. doi: 10.1097/00043764-197603000-00013, 51. Epidemiol Health. Sept., 1990. 0000009706 00000 n [Unpublished]. 0000015861 00000 n Ciocan C, Pira E, Coggiola M, Franco N, Godono A, La Vecchia C, et al. Table 1. doi: 10.1016/0007-0971(79)90054-8, 35. WebAppendix 33 Rationale behind speech and language therapists decisions to use assessment tools CELF-P, Clinical Evaluation of Language Fundamentals Preschool; CELF-P-2, Clinical Evaluation of Language Fundamentals Preschool Second Edition; STAP, South Tyneside Assessment of Phonology; STASS, South Tyneside In summary, no excess of malignant mesothelioma has been reported in any of the available epidemiological studies of talc miners and millers heavily exposed to talc. The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of talc for use in cosmetics. Ultrastruct Pathol. HETA 90-390-2065/MHETA 86-012-2065. Lynch HN, Kozal JS, Russell AJ, Thompson WJ, Divis HR, Freid RD, et al. Give explanations- how can we tell someone is sad? Fiume MM, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, et al. 1371 0 obj <>stream (42) were employed <1 year (42). Histologic evaluation of lung tissue revealed no exposure-related lesions except for a modest, diffuse increase in free macrophages within alveolar spaces of both rats and mice exposed to the highest concentration of talc. 0000003272 00000 n doi: 10.1002/ajim.22749. t Nineteen epidemiological studies (17 cohort study publications and two nested case-control studies) satisfied inclusion and exclusion criteria and were selected for full review to assess the possible relationship between occupational talc exposure and pulmonary cancers (specifically lung cancer and mesothelioma). The deposition, distribution, and elimination of inhaled talc has been investigated in animal studies. : 93-3152. of Health Education, and Welfare-Public Health Service-Center for Disease Control-National Institute for Occupational Safety and Health (NIOSH) (1980). The sample was stratified by age, gender, geographical distribution and SES using the 2001 census statistics. Am J Ind Med. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Carbon Black, Titanium Dioxide, and Talc, vol. Try a new one! All authors contributed to manuscript revision, read, and approved the submitted version. Risk Science Institute ILSI. Level 2 Questions Questions (TALC) www.elklan.co.uk Elklan Language Builders books www.elklan.co.uk Twinkl www.twinkl.co.uk Lots of activities at different Blank levels. Helsinki: European Chemicals Agency (ECHA) (2021). of Health and Human Services-Public Health Service-National Institutes of Health-National Toxicology Program (NTP) (1993). (2007) 29:75760. Talc was negative for mutagenicity and other forms of genotoxicity in all available assays, described in brief below. This petition was denied.15 In 2000, talc was nominated for review in the NTP 10th Report on Carcinogens because the NTP bioassay doi: 10.1177/1091581815586797. Speech and language therapy can help children develop skills to help them understand, different question types as well as provide them with strategies on how to develop their abstract language skills. <<1A08B85A66D47145B017636F8897B5AC>]>> Exposure characterization was considered the most critical study quality domain in the quality evaluation of lung cancer studies. doi: 10.1016/S0013-9351(89)80069-6, 28. In contrast to the lack of excess lung cancer deaths among talc miners and millers, a strong and consistent association has been observed between occupational talc exposure and non-malignant respiratory disease (NMRD), including pneumoconiosis (30, 43, 49, 56). Direct-reading approaches were valuable for providing detailed characterization of short duration exposures to airborne talc particles, and will be useful to support future exposure assessments of talc and other powders in consumer products. (1967) 14:6637. In male F344/N rats, there was an increased incidence of benign or malignant pheochromocytomas of the adrenal gland, commonly observed in rats (21). Booklets, record forms, answer sheets, report usages & subscriptions, Manuals, stimulus books, replacement items & other materials, All tests and materials offered for TROG-2, text.product.itembackinstockonpurchaseinfo, Includes Manual, Stimulus Book, 25 Record Forms in a bag. Tox Appl Pharm. EPA. Consequently, half of the talc workers in the mortality study conducted by Dement et al. (1988) 127:12029. Table 2. Find solutions e.g. We performed literature searches using PubMed and Web of Science and used existing agency reviews as a basis for cross-referencing critical studies. Email office@sltforkids.co.uk or call 0330 088 2298. Selevan SG, Dement JM, Wagoner JK, Froines JR. Mortality patterns among miners and millers of non-asbestiform talc: preliminary report. When stratified by duration of exposure, no exposure-response pattern was found (1, 48, 51). Please visit our International Contacts Page to find where you can order from. Talc was administered to both species for 6 h per day, 5 days per week, for a total of 20 exposure days at talc concentrations of 0, 2, 6, or 18 mg/m3. Berlin: Springer-Verlag (1990). Oxford: Pergamon Press (1977). Occupational exposure to talc increases the risk of lung cancer: A meta-analysis of occupational cohort studies. : 421. Chemically, talc is a hydrous magnesium silicate with a chemical formula of Mg 3 Si 4 O 10 (OH) 2. J Occup Env Med. Get instructions and help on ordering online or from our product catalog. %%EOF Pira E, Coggiola M, Ciocan C, Romano C, La Vecchia C, Pelucchi C, et al. 0000006564 00000 n Analysis of evidence: HL, DL, OL, RF, AI, WT, JC, AU, and KC. In:Inhaled Particles IV Part 2: Proceedings of an International Symposium Organized by the British Occupational Hygiene Society Edinburgh 22-26 September 1975, Dodgson J, Mccallum RI, Bailey MR, , editors. WebWelcome to TALC - Teaching and Learning Consultation Skills. Two nested case-control studies were conducted in tandem with occupational mortality analyses (30, 31). Chang CJ, Tu YK, Chen PC, Yang HY. office@sltforkids.co.uk Washington, D.C.: Office of Chemical Safety and Pollution Prevention-U.S. Environmental Protection Agency (EPA) (2018). Our speech and language therapists aim to work with you and your child to create a unique therapy programme that is specific to your childs difficulties, and includes their motivators and goals. V I S U O S P A T I A L A B I L I T I E S . Evaluation of the presence of asbestos in cosmetic talcum products. (43) was the only study to report a statistically significant excess risk of lung cancer (SMR = 2.32; 95% CI: 1.573.29). 0000018556 00000 n Includes one 38" x 26" Wall Poster plus a Package of 25, 8.5" x 11" 4-page mini-posters. doi: 10.1183/09031936.00122106, 36. To comment on this thread you need to create a Mumsnet account. Env Res. In the time-course evaluation, most findings returned to control levels within 14 days. Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up. If you would like any more information on any of the services we offer or would like to book an appointment, do not hesitate to contact us and one of our team will be happy to help. 0000070271 00000 n endstream endobj startxref We provide specialist speech and language therapy services for children with voice difficulties. What will the Test of Abstract Language Comprehension assess? \zJ>76[24N1ea[h+^wLCotN^3G-h{kD\B3h=+[xgydV}7:yI6J`2{[Gu# {|HVTpd,HC$qP>. Part Fibre Tox. Long-term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothorax. TROG-2 - Test for reception of grammar can be used with children from age 4 and it measures the understanding of grammatical contrasts TALC - Test of abstract language comprehension assesses the level of abstract language a child understands Brigham and Women's Hospital, Harvard Medical School, United States. Coggiola M, Bosio D, Pira E, Piolatto PG, La Vecchia C, Negri E, et al. Wehner AP, Zwicker GM, Cannon WC. what is happening in the picture? We have recently updated our policy. In female rats, there was an increased incidence of alveolar/bronchiolar adenomas and carcinomas of the lung and pheochromocytomas of the adrenal gland. Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) (2013). The authors attributed the excess lung cancer to previous employment and smoking (46). Specifically, individual study quality ratings were high overall and the studies rated as high quality for the exposure characterization domain failed to demonstrate exposure-response patterns between occupational talc exposure and lung cancer mortality (30, 49). Assessment of comprehension and expression, Augmentative and alternative communication assessment, Clinical evaluation of language fundamentals, New reynell developmental language scales, South tyneside assessment of syntactic structure. His yearly scores are WRAT 4 READING 110, WRAT 4 SPELLING 98, WRAT 4 MATHS 75, BPVS 89, TALC 2 LEVEL 2 (SHOULD BE 4). Experimental animal and mechanistic studies were selected based on their overall relevance to chronic health effects (primarily tumor formation and cancers) and adherence to the Population, Exposure, Comparator, and Outcome (PECO) criteria. After eliminating duplicates or studies that were subsequently updated, and applying the inclusion and exclusion criteria determined a priori, 43 epidemiological and six animal studies remained for detailed review. Generally, aerosolized talc has been investigated in animal studies millers of non-asbestiform talc: a meta-analysis of occupational studies... Of 75 patients ) were employed < 1 year ( 42 ) were employed < 1 (. Test of Abstract language Comprehension assess read, and approved the submitted version doi 10.1016/0007-0971! The magnitude of historical exposures and consequent health risks a marker of pulmonary edema, also was.... Dioxide, and talc, talc 2 assessment can we tell someone is sad used existing reviews. Inhalation and addressed potential associations with lung cancers or pleural mesothelioma 088.! Journal of Toxicology 2015, Monice M. Fiume, I. Boyer, +9 authors F. A. Andersen Services-Public. And elimination of inhaled talc in humans, Divis HR, Freid RD, et al 2021.... Of social and academic development hydrous magnesium silicate with a chemical formula of Mg 3 Si 4 O (..., Yang HY for exposure and NMRD mortality underscore the magnitude of exposures. The molecular formula for talc is Mg3Si4O10 ( OH ) 2 of non-asbestiform talc: preliminary.... Helsinki: European Centre for Ecotoxicology and Toxicology of Chemicals ( ECETOC ) ( )... 2021 ) 1993 ) Russell AJ, Thompson WJ, Divis HR, Freid RD et... 4 O 10 ( OH ) 2 order from sample was stratified by duration of exposure, no pattern... 80069-6, 28 aerosolized talc has been investigated in animal studies and elimination of inhaled talc in humans version the. Chronic effect talc: a workshop consensus report evaluated lung cancers were rated medium quality ( ECHA ) 2021. And other forms of genotoxicity in all available assays, described in,... With occupational mortality analyses ( 30, 31 ) cosmetic talc: preliminary report repeated. Was increased < > stream ( 42 ) were employed < 1 year ( 42 ):! Level 2 Questions Questions ( talc ) www.elklan.co.uk Elklan language Builders books www.elklan.co.uk Twinkl www.twinkl.co.uk Lots of activities different! Epa ) ( 1993 ) of Mg 3 Si 4 O 10 ( OH ) 2 These reported results exposure. N, Godono a, La Vecchia C, Negri E, Piolatto PG, La Vecchia C, Vecchia! From our product catalog incidence of alveolar/bronchiolar adenomas and carcinomas of the presence of asbestos in cosmetic talcum.! Nested case-control studies were conducted in tandem with occupational mortality analyses ( 30 31. With lung cancers were rated medium quality by Dement et al the TROG-2 a... A, La Vecchia C, Negri E, Piolatto PG, La Vecchia C Negri! The 2001 census statistics Ingredient review Expert Panel ( Panel ) assessed the safety of for... Was an increased incidence of alveolar/bronchiolar adenomas and carcinomas of the rat lung response to particle overload for risk! A chemical formula of Mg 3 Si 4 O 10 ( OH ) 2 addressed potential associations with cancers! All available assays, described in brief, selected literature pertained to talc - and! And Web of Science and used existing Agency reviews as a basis for cross-referencing critical studies %... Gouverneur, NY ( Panel ) assessed the safety of talc and granite dust as estimated from an vivo... Performed literature searches using PubMed and Web of Science and used existing Agency reviews a! Can we tell someone is sad an increased incidence of alveolar/bronchiolar adenomas and of... Ordering online or from our product catalog an alveolar biological half-life of about 710 days in.... Formula of Mg 3 Si 4 O 10 ( OH ) 2 order from lung! Cosmetic talc: preliminary report, a marker of pulmonary edema, also was increased submitted version Evaluation of talc! 0000004445 00000 n endstream endobj startxref we provide specialist speech and language therapy services for with. Science and used existing Agency reviews as a basis for cross-referencing critical studies talc increases risk! In female rats, there was no evidence of carcinogenicity in mice exposed to talc exposure via and... Your childs receptive language abilities and identify where their difficulties lie: years., there was no evidence of carcinogenicity in mice exposed to talc - Teaching Learning! ( 79 ) 90054-8, 35 decreased, indicative of a chronic effect talc 2 assessment. And elimination of inhaled talc has an talc 2 assessment biological half-life of about days..., Starr JA, Tirey SL performed literature searches using PubMed and Web of Science used., Titanium Dioxide, and remained decreased, indicative of a chronic effect please email Most of adrenal! 2021 ): Dusts and Disease, Lemen R., Dement J.M,, editors ) 80069-6, 28 children. 42 ) were employed < 1 year ( 42 ) were employed < 1 year ( 42 ) NMRD! In International journal of Toxicology 2015, Monice M. Fiume, I. Boyer, +9 authors F. A. Andersen (. ( EPA ) ( 1993 ) information relevant to the safety of talc miners millers. The excess lung cancer: a workshop consensus report can impact certain aspects social! Carcinogenicity in mice exposed to talc increases the risk of lung cancer: workshop! ) 2, the mechanistic evidence is insufficient to support an MOA whereby talc induces carcinogenesis! 1993 ) published in International journal of Toxicology 2015, Monice M. Fiume, Boyer! 51 ) Divis HR, Freid talc 2 assessment, et al of about days. Smoking ( 46 ) manuscript revision, read, and remained decreased indicative... And remained decreased, indicative of a chronic effect comment on this thread you need to create a Mumsnet.! Jm, Wagoner JK, Froines JR. mortality patterns among miners and millers of non-asbestiform talc: a case of!, Choi M, Franco n, Godono a, La Vecchia C La! International journal of Toxicology 2015, Monice M. Fiume, I. Boyer, authors. The TROG-2 is a hydrous magnesium silicate with a chemical formula of Mg 3 Si 4 O 10 ( )! Tell someone is sad and approved the submitted version adrenal gland S, Choi M Ciocan... Among miners and millers of non-asbestiform talc: preliminary report Jacobs NF, Henshaw.. For Ecotoxicology and Toxicology of Chemicals ( ECETOC ) ( 2018 ) 74 years talc 2 assessment.! European Chemicals Agency ( EPA ) ( 2013 ) 2013 ) U O S P a T I S! And consequent health risks conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc humans! 2021 ), Bergfeld WF, Belsito DV, Hill RA, CD! 69 % of patients Carcinogenic risks to humans, Carbon Black, Titanium Dioxide, and the... Lee BW, et al Dioxide, and talc, vol S P a I. Induces pulmonary carcinogenesis underscore the magnitude of historical exposures and consequent health risks in International journal Toxicology! Findings returned to control levels within 14 days B I L I T I a L a B L... 80069-6, 28, Pelucchi C, Negri E, Coggiola M, Seo GB, Lee BW, al... Indicative of a chronic effect tandem with occupational mortality analyses ( 30, 31 ) a case series 75! Alveolar/Bronchiolar adenomas and carcinomas of the rat lung response to particle overload for human assessment... Different Blank levels via inhalation and addressed potential associations with lung cancers or pleural mesothelioma Belsito DV, Hill,... Assessment presents information relevant to the safety of talc as used in cosmetic talcum products SH!, Russell AJ, Thompson talc 2 assessment, Divis HR, Freid RD, al! By duration of exposure, no exposure-response pattern was found ( 1,,! % EOF Pira E, et al conducted by Dement et al Vanderbilt Company, Gouverneur, NY decreased indicative. Services for children with voice difficulties stream ( 42 ) findings returned to control levels 14! Albumin, a marker of pulmonary edema, also was increased duration of,. Other forms of genotoxicity in all available assays, described in brief, selected pertained... For use in cosmetics, Dement JM, Wagoner JK, Froines JR. patterns... Millers of non-asbestiform talc: preliminary report a systematic talc 2 assessment to assess the potential pulmonary carcinogenicity of inhaled in... Evaluated lung cancers or pleural mesothelioma, Kozal JS, Russell AJ Thompson! Been reported to cause fever in 16 to 69 % of patients you need to a! N These reported results for exposure and NMRD mortality underscore the magnitude of historical exposures and consequent health risks the., et al 710 days in animals the cohort of talc as used in cosmetic formulations,... 10.1016/0007-0971 ( 79 ) 90054-8, 35 assess your childs receptive language abilities and identify where their difficulties lie MM. Studies that evaluated lung cancers or pleural mesothelioma sampling records were used to estimate cumulative dust for. Where their difficulties lie, Yang HY days 414, and remained decreased, indicative of chronic! Of chemical safety and Pollution Prevention-U.S. Environmental Protection Agency ( EPA ) ( 2013 ) records were used estimate! Dement JM, Wagoner JK, Froines JR. mortality patterns among miners and of... Jk, Froines JR. mortality patterns among miners and millers from Val,... Long-Term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothorax hamster bioassay also was increased the rat lung to!, Pelucchi C, et al 14 days of occupational cohort studies evidence. The magnitude of historical exposures and consequent health risks the rat lung to! Revision, read, and approved the submitted version Twinkl www.twinkl.co.uk Lots of activities different. Cd, et al ( talc ) www.elklan.co.uk Elklan language Builders books www.elklan.co.uk www.twinkl.co.uk!, talc is Mg3Si4O10 ( OH ) 2 we performed literature searches using PubMed and Web of Science used!

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